Раздел медицины:
Биотехнологии и биоматериалы

Application of biocompositional material

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Vasiliev MG, Panasyuk AF, Larionov EV, Lekishvili MV. Central Institute of Traumatology and
Orthopaedics (CITO). Connectbiofarm LTD. Moscow, Russia.

The search for materials stimulating reparative osteogenesis after bone plastics remains very urgent. The problems connected with application of different allografts for filling bone defects are of special importance for practical traumatology and orthopaedics.

The investigation of the connective tissue components, i.e. sulfated glycosaminoglycans (sGAG), showed that these compositional polysacharides can influence the reparation of the connective tissue. The aim of this work was to study the effect of the new biocompositional material “Osteomatrix” on the osteogenesis induction while treating patients with tumors, tumor-like diseases, posttraumatic complications, false joints.

This material was produced on the basis of bone collagen and saturated with bone sGAG. The most important property of “Osteomatrix” is that alongside with osteoconductive effect (long-term volume support and frame function) it can cause osteoinductive effect due to sGAG. This biocompositional material is produced in the form of granule (0.2-0.4cm3 ) and blocks (4-
10 cm3 ).

From May to December 2001 “Osteomatrix” was used in CITO clinics for treatment of 14 children and 32 adults. The patients were followed up not less than 6 months. The results obtained show that when placed into the bone defect “Osteomatrix” influences actively the regeneration of the bone tissue at the site of the bone pathology. Formation of the X-ray detectable dense substance occurs very quickly beginning with the first month after transplantation and completes by the sixth month resulting in spongy bone. Absence of any inflammation caused by the implanted material confirmed its low antigenicity and high integrity in the recipient’s tissue.

Granulated “Osteomatrix” was used successfully for filling of not big (up to 10cm3 )bone defects. It should be noted that the bone injuries caused by traumas or different pathologies may be considerable and require a large amount of filling material. Hence “Osteomatrix” in blocks 6-10cm3 is used in CITO clinics giving additional advantage of creating stable supporting structure which is quite necessary in the loaded parts of the injured bone.

Clinical application of biocompositional materials enables controlling the processes of bone tissue reparation. Various geometry of allografts, the degree of their demineralization, their biomechanical parameters and biocompositional material with particular properties will allow to choose proper plastic material or its combinations for surgery operations in every case of bone pathology.

American Association of Tissue Banks
26th Annual Meeting Boston, Massachusetts August 23-27, 2002
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